机器人辅助腹腔镜子宫肌瘤切除术与开腹子宫肌瘤切除术:短期手术结果及直接成本比较

Robot-assisted laparoscopic myomectomy versus abdominal myomectomy: a comparison of short-term surgical outcomes and immediate costs.

作者信息

Advincula Arnold P, Xu Xiao, Goudeau Suntrea, Ransom Scott B

机构信息

Department of Obstetrics and Gynecology, University of Michigan Medical Center, Women's Hospital, Ann Arbor, MI 48109, USA.

出版信息

J Minim Invasive Gynecol. 2007 Nov-Dec;14(6):698-705. doi: 10.1016/j.jmig.2007.06.008.

Abstract

STUDY OBJECTIVE

To compare surgical outcomes of myomectomy by robot-assisted laparoscopy with those performed by traditional laparotomy and to analyze the financial impact of these 2 approaches.

DESIGN

Retrospective case-matched analysis (Canadian Task Force classification III).

SETTING

University teaching hospital.

PATIENTS

A total of 58 patients with symptomatic leiomyomata.

INTERVENTION

Myomectomy by robot-assisted laparoscopy or traditional laparotomy was administered.

MEASUREMENTS AND MAIN RESULTS

An equal number of case-matched patients based on age, body mass index, and myoma weight were analyzed in each group. Among these 3 variables, there were no statistically significant differences between the robotic and laparotomy groups. Mean age was 36.59 +/- 4.93 years (95% CI 34.71-38.46 years) versus 34.86 +/- 4.41 years (95% CI 33.18-36.54 years), mean body mass index was 25.22 +/- 3.85 kg/m(2) (90% central range [CR] 20.30-31.20 kg/m2) versus 28.3 +/- 6.95 kg/m2 (90% CR 21.50-42.80 kg/m2), and mean myoma weight was 227.86 +/- 247.54 g (90% CR 11.60-680.00 g) versus 223.76 +/- 228.28 g (90% CR 11.50-660.00 g), respectively. Patients with robot-assisted laparoscopic myomectomy had decreased estimated blood loss (mean 195.69 +/- 228.55 mL [90% CR 50.00-700.00 mL] vs mean 364.66 +/- 473.28 mL [90% CR 75.00-1550.00 mL]) and length of stay (mean 1.48 +/- 0.95 days [90% CR 1.00-3.00 days] vs mean 3.62 +/- 1.50 days [90% CR 3.00-8.00 days]) when compared with the laparotomy group. Both of these differences were statistically significant at p <.05. Operative times were significantly longer in the robotic group: mean 231.38 +/- 85.10 minutes (95% CI 199.01-263.75 minutes) versus mean 154.41 +/- 43.14 minutes (95% CI 138.00-170.82 minutes, p <.05) in the laparotomy group. Complication rates were higher in the laparotomy group. Professional charges (mean $5946.48 +/- $1447.17 [90% CR $4034.46-$8937.00] vs mean $4664.48 +/- $642.11 [90% CR $3944.36-$6010.90, p <.0002]) and hospital charges (mean $30084.20 +/- $6689.29 [90% CR $22939.81-$45588.22] vs mean $13400.62 +/- $7747.26 [90% CR $8703.20-$26771.22, p <.0001]) were statistically higher for the robotic group. Although professional reimbursement was not significantly different between groups (mean $2263.02 +/- $1354.97 [90% CR $0.00- $4831.08] versus mean $1841.99 +/- $827.51 [90% CR $0.00-$3376.97, p = .2831]), mean hospital reimbursement rates for the robotic group were significantly higher: $13181.39 +/- $10752.00 (90% CR $1081.76-$37396.03) versus $7015.24 +/- $3467.97 (90% CR $2492.48-$10394.83, p = .0372).

CONCLUSION

As a new technology, it is not unexpected that a robotic approach to myomectomy costs more than a traditional laparotomy. On the other hand, decreased estimated blood loss, complication rates, and length of stay with the robotic approach in the end may prove to have a significant societal benefit that will outweigh upfront financial impact.

摘要

研究目的

比较机器人辅助腹腔镜子宫肌瘤切除术与传统剖腹手术的手术效果,并分析这两种手术方式的经济影响。

设计

回顾性病例匹配分析(加拿大工作组分类III级)。

地点

大学教学医院。

患者

共58例有症状的子宫肌瘤患者。

干预措施

采用机器人辅助腹腔镜或传统剖腹手术进行子宫肌瘤切除术。

测量指标及主要结果

每组根据年龄、体重指数和肌瘤重量进行病例匹配分析,病例数相等。在这三个变量中,机器人手术组和剖腹手术组之间无统计学显著差异。平均年龄分别为36.59±4.93岁(95%CI 34.71 - 38.46岁)和34.86±4.41岁(95%CI 33.18 - 36.54岁);平均体重指数分别为25.22±3.85 kg/m²(90%中心范围[CR] 20.30 - 31.20 kg/m²)和28.3±6.95 kg/m²(90%CR 21.50 - 42.80 kg/m²);平均肌瘤重量分别为227.86±247.54 g(90%CR 11.60 - 680.00 g)和223.76±228.28 g(90%CR 11.50 - 660.00 g)。与剖腹手术组相比,机器人辅助腹腔镜子宫肌瘤切除术患者的估计失血量减少(平均195.69±228.55 mL[90%CR 50.00 - 700.00 mL]对平均364.66±473.28 mL[90%CR 75.00 - 1550.00 mL]),住院时间缩短(平均1.48±0.95天[90%CR 1.00 - 3.00天]对平均3.62±1.50天[90%CR 3.00 - 8.00天])。这两个差异在p<0.05时均具有统计学显著性。机器人手术组的手术时间显著更长:平均231.38±85.10分钟(95%CI 199.01 - 263.75分钟),而剖腹手术组平均为154.41±43.14分钟(95%CI 138.00 - 170.82分钟,p<0.05)。剖腹手术组的并发症发生率更高。机器人手术组的专业费用(平均5946.48±1447.17美元[90%CR 4034.46 - 8937.00美元]对平均4664.48±642.11美元[90%CR 3944.36 - 6010.90美元,p<0.0002])和医院费用(平均30084.20±6689.29美元[90%CR 22939.81 - 45588.22美元]对平均13400.62±7747.26美元[90%CR 8703.20 - 26771.22美元,p<0.0001])在统计学上更高。虽然两组之间的专业报销无显著差异(平均2263.02±1354.97美元[90%CR 0.00 - 4831.08美元]对平均1841.99±827.51美元[90%CR 0.00 - 3376.97美元,p = 0.2831]),但机器人手术组的平均医院报销率显著更高:13181.39±1075(90%CR 1081.76 - 37396.03美元)对7015.24±3467.97美元(90%CR 2492.48 - 10394.83美元,p = 0.0372)。

结论

作为一项新技术,机器人辅助子宫肌瘤切除术的成本高于传统剖腹手术并不意外。另一方面,机器人手术方式估计失血量减少、并发症发生率降低以及住院时间缩短,最终可能证明具有显著的社会效益,超过前期的经济影响。

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