强效杂环恶唑烷酮的合成、抗菌活性及RBx 8700的鉴定
Synthesis and antibacterial activity of potent heterocyclic oxazolidinones and the identification of RBx 8700.
作者信息
Rudra Sonali, Yadav Ajay, Raja Rao A V S, Srinivas A S S V, Pandya Manisha, Bhateja Pragya, Mathur Tarun, Malhotra Sunita, Rattan Ashok, Salman Mohammed, Mehta Anita, Cliffe Ian A, Das Biswajit
机构信息
Department of Medicinal Chemistry, New Drug Discovery Research, Ranbaxy Laboratories Limited, R&D III, Plot No. 20, Sector-18, Udyog Vihar Industrial Area, Gurgaon, Haryana 122015, India.
出版信息
Bioorg Med Chem Lett. 2007 Dec 15;17(24):6714-9. doi: 10.1016/j.bmcl.2007.10.061. Epub 2007 Oct 22.
Several potent oxazolidinone antibacterial agents were obtained by systematic modification of the linker between the five-membered heterocycle and the piperazinyl ring of RBx 7644 (Ranbezolid, 1) and its thienyl analogue 2, leading to the identification of an expanded spectrum compound RBx 8700 (6b).
通过对RBx 7644（瑞奈唑胺，1）及其噻吩类似物2的五元杂环与哌嗪环之间的连接基团进行系统修饰，获得了几种强效恶唑烷酮类抗菌剂，从而鉴定出一种广谱化合物RBx 8700（6b）。
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