Ocal G, Kokcu A, Cetinkaya M B, Tosun M, Kefeli M, Kandemir B
Department of Obstetrics and Gynecology, School of Medicine, University of Ondokuz Mayis, Samsun, Turkey.
Int J Gynaecol Obstet. 2007 Oct;99(1):38-42. doi: 10.1016/j.ijgo.2007.04.041. Epub 2007 Aug 3.
To investigate the efficacy of levamisole on experimental endometriosis.
After the implantation of endometrial tissue on abdominal peritoneum, 40 rats were randomized to 1 of 4 equal intervention groups. Levamisole (2 mg/rat) was applied subcutaneously to group "L" once a week. Depot medroxyprogesterone acetate (3 mg/kg) was applied intramuscularly to group "M" twice at 4-week intervals. Leuprolide (0.075 mg/kg) was applied subcutaneously to group "G" twice at 4-week intervals. Saline (0.1 cm(3)/rat) was applied subcutaneously to group "C" once a week for 8 weeks. The efficacy of levamisole was determined by volume measurement and characterizing the histological structure of the implants.
Volume increase of the implants in group C (P<0.05), and volume decrease in groups M, G, and L was found (P<0.05, P<0.01, and P<0.01, respectively.) Stromal tissue and glandular activity were not different between groups L and G.
Levamisole was found to be as effective as leuprolide in regression of the volume of endometriotic implants.
研究左旋咪唑对实验性子宫内膜异位症的疗效。
将子宫内膜组织植入大鼠腹腔腹膜后，40只大鼠被随机分为4个相等的干预组。“L”组大鼠每周皮下注射一次左旋咪唑（2毫克/只）。“M”组大鼠每隔4周肌肉注射一次醋酸甲羟孕酮长效注射液（3毫克/千克），共注射两次。“G”组大鼠每隔4周皮下注射一次亮丙瑞林（0.075毫克/千克），共注射两次。“C”组大鼠每周皮下注射一次生理盐水（0.1立方厘米/只），持续8周。通过测量植入物的体积并对其组织结构进行特征描述来确定左旋咪唑的疗效。
发现“C”组植入物体积增加（P<0.05），而“M”组、“G”组和“L”组植入物体积减小（分别为P<0.05、P<0.01和P<0.01）。“L”组和“G”组之间的间质组织和腺体活性没有差异。
发现左旋咪唑在使子宫内膜异位症植入物体积缩小方面与亮丙瑞林效果相同。
