Chan Shih-Peng, Slack Frank J
Department of Molecular, Cellular and Developmental Biology, Yale University, P.O. Box 208103, New Haven, CT 06520, USA.
Department of Molecular, Cellular and Developmental Biology, Yale University, P.O. Box 208103, New Haven, CT 06520, USA.
Dev Cell. 2007 Nov;13(5):605-607. doi: 10.1016/j.devcel.2007.10.010.
Mirtrons are short hairpin introns recently found in flies and nematodes that provide an alternative source for animal microRNA biogenesis and use the splicing machinery to bypass Drosha cleavage in initial maturation. The presence of mirtrons outside of invertebrates was not previously known. In the October 26 issue of Molecular Cell, Berezikov et al. expose a number of short mammalian introns as mirtrons.
微小内含子是最近在果蝇和线虫中发现的短发夹内含子,它们为动物微小RNA的生物合成提供了一种替代来源,并利用剪接机制在初始成熟过程中绕过 Drosha 切割。此前尚不清楚无脊椎动物之外是否存在微小内含子。在10月26日的《分子细胞》杂志上,贝雷齐科夫等人揭示了许多短的哺乳动物内含子是微小内含子。