Labens R, Mellor D J, Voûte L C
Weipers Centre for Equine Welfare, Division of Companion Animal Sciences, Institute of Comparative Medicine, University of Glasgow Veterinary School, Glasgow, UK.
Vet Rec. 2007 Nov 3;161(18):611-6. doi: 10.1136/vr.161.18.611.
Osteoarthritis of the distal tarsal joints, affecting the centrodistal and tarsometatarsal joints, is a common cause of hindlimb lameness in horses. This paper describes the outcome of the intra-articular treatment of 51 horses with the condition with either methylprednisolone acetate (mpa) or triamcinolone acetonide (tr), either with or without hyaluronic acid (ha). The outcome was assessed in terms of the changes in the horses' grade of lameness. Follow-up information was obtained from the owners by means of a telephone questionnaire. Horses treated once with mpa or tr, either with or without ha, improved after a median of 56 days (P<0.0001), and there was no significant difference between mpa and tr. There was no significant further improvement in the horses treated twice. In the horses in which there was a diffuse increase in the uptake of a radiopharmaceutical by the distal tarsal joints, identified by scintigraphy, the lameness tended to improve (P=0.032), whereas in the horses in which the uptake was focal, it did not. At telephone follow-up 13 of 34 horses were reported to have had a positive outcome, but the outcome in the other 21 was reported to have been negative.
跗关节远端的骨关节炎，累及中央远端关节和跗跖关节，是马后肢跛行的常见原因。本文描述了对51匹患有该病症的马进行关节内治疗的结果，治疗药物为醋酸甲基泼尼松龙（mpa）或曲安奈德（tr），同时使用或不使用透明质酸（ha）。根据马匹跛行程度的变化评估治疗结果。通过电话问卷从马主那里获取随访信息。用mpa或tr治疗一次的马匹，无论是否使用ha，在中位数为56天后均有所改善（P<0.0001），且mpa和tr之间无显著差异。接受两次治疗的马匹没有显著的进一步改善。在通过闪烁扫描术确定跗关节远端放射性药物摄取弥漫性增加的马匹中，跛行倾向于改善（P=0.032），而在摄取为局灶性的马匹中则不然。在电话随访中，34匹马中有13匹报告有阳性结果，但另外21匹报告为阴性结果。
