Alves João C, Santos Ana, Jorge Patrícia, Lavrador Catarina, Carreira L Miguel
Divisão de Medicina Veterinária, Guarda Nacional Republicana (GNR), Lisbon, Portugal.
MED - Mediterranean Institute for Agriculture, Environment and Development, Instituto de Investigação e Forma Avana, Universidade de Évora, Évora, Portugal.
Front Vet Sci. 2021 Jan 18;7:609889. doi: 10.3389/fvets.2020.609889. eCollection 2020.
To compare the effect of intra-articular treatment with triamcinolone hexacetonide (TH), stanozolol, hyaluronan, and a platelet concentrate in police working dogs with bilateral hip osteoarthritis (OA). Prospective, longitudinal, double-blinded, negative controlled study. Fifty police working dogs with naturally occurring hip OA. Animals were randomly assigned to a control group (CG, = 10), TH group (THG, = 10), platelet concentrate group (PCG, = 10), stanozolol group (SG, = 10), and Hylan G-F 20 group (HG). On days 0 (T0), 8, 15, 30, 90, and 180 days post-treatment, weight-bearing distribution was evaluated. In those days, and on days 60, 120, and 150, four clinical metrology instruments were completed. Kaplan-Meier estimators were conducted and compared with the log-rank test. Cox proportional hazard regression analysis was performed to determine treatment survival. Significance was set at < 0.05. Patients had a mean age of 6.5 ± 2.4 years and body weight of 26.7 ± 5.2 kg. At T0, hips were classified as mild ( = 35), moderate ( = 10), and severe ( = 5), according to the Orthopedic Foundation for Animals grading scheme. No differences were found between groups at that moment considering age, body weight, OFA hip score, and all assessments performed. All treatments improved clinical signs in various OA dimensions in some groups, with a broad effect interval. PCG showed a lower range of variation while maintaining a positive result for more extended periods ( < 0.01 for symmetry index and 0.01 < < 0.04 in the majority of scores). Breed, age, sex, and OFA grade did not significantly influence response to treatment. This is the first prospective, negative controlled, double-blinded study to compare the effect of a single administration of these IA treatments in dogs with hip OA. HG and PCG recorded more significant improvements throughout the 180-day follow-up. In particular, PCG also registered a lower variation in results, seemingly the best therapeutic option. Nevertheless, improvements were still observed in THG and SG, and these treatment options can be considered, mainly when the first two treatments are not available.
比较己曲安奈德（TH）、司坦唑醇、透明质酸和血小板浓缩物关节内治疗对双侧髋关节骨关节炎（OA）警犬的效果。前瞻性、纵向、双盲、阴性对照研究。50只自然发生髋关节OA的警犬。动物被随机分为对照组（CG，n = 10）、TH组（THG，n = 10）、血小板浓缩物组（PCG，n = 10）、司坦唑醇组（SG，n = 10）和Hylan G-F 20组（HG）。在治疗后第0天（T0）、8天、15天、30天、90天和180天，评估负重分布。在这些日子以及第60天、120天和150天，完成四项临床计量仪器检查。进行Kaplan-Meier估计并与对数秩检验进行比较。进行Cox比例风险回归分析以确定治疗生存率。显著性设定为P < 0.05。患者平均年龄为6.5±2.4岁，体重为26.7±5.2 kg。根据动物骨科基金会分级方案，在T0时，髋关节分为轻度（n = 35）、中度（n = 10）和重度（n = 5）。当时在年龄、体重、OFA髋关节评分以及所有评估方面，各组之间未发现差异。所有治疗在某些组中在不同OA维度上改善了临床症状，效果区间较宽。PCG显示变化范围较小，同时在更长时间内保持阳性结果（对称指数P < 0.01，大多数评分中0.01 < P < 0.04）。品种、年龄、性别和OFA等级对治疗反应无显著影响。这是第一项前瞻性、阴性对照、双盲研究，比较这些关节内治疗单次给药对髋关节OA犬的效果。在180天的随访中，HG和PCG记录了更显著的改善。特别是，PCG的结果变化也较小，似乎是最佳治疗选择。然而，在THG和SG中仍观察到改善，并且这些治疗选择可以考虑，主要是在前两种治疗不可用时。
