Tsukui Tohru, Imazawa Yukiko, Inoue Satoshi
Saitama Medical University, Research Center for Genomic Medicine.
Clin Calcium. 2007 Nov;17(11):1685-91.
Two pathways that mediate vitamin K (VK) action in the bone metabolism have been identified. One pathway is well known mechanism, that mediates the posttranslational modification of the target proteins by VK dependent gamma-carboxylase (GGCX). The other pathway is a novel one, that mediates the transcriptional regulation of the target genes by SXR, steroid and xenobiotic receptor. Both mechanisms of VK are involved in modulation of extracellular matrix proteins in the bone.
已确定两条介导维生素K（VK）在骨代谢中作用的途径。一条途径是众所周知的机制，即通过VK依赖性γ-羧化酶（GGCX）介导靶蛋白的翻译后修饰。另一条途径是新发现的途径，即通过类固醇和外源性物质受体（SXR）介导靶基因的转录调控。VK的这两种机制都参与了骨中细胞外基质蛋白的调节。
