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[血清维生素K浓度与营养]

[Serum vitamin K concentration and nutrition].

作者信息

Tsugawa Naoko, Okano Toshio

机构信息

Kobe Pharmaceutical University, Department of Hygienic Sciences.

出版信息

Clin Calcium. 2007 Nov;17(11):1717-26.

Abstract

Vitamin K (VK) is well known for its role in the synthesis of a number of blood coagulation factors. VK is also an important factor for bone metabolism via gamma-carboxylation of VK-dependent proteins such as osteocalcin, matrix Gla protein, and protein S. Recently, it is rare that severe VK deficiency is observed. However, low dietary VK intake or low VK status has been shown to be associated with low bone mineral density and increased hip fracture risk. These studies suggest that there is potential VK insufficiency in bone, even in sufficient VK status for blood coagulation. In the present review, the studies concerning relationship between serum VK concentration and bone health, including pharmacokinetics of VK analogues (such as phylloquinone and menaquinone) and factors which affect on blood circulation of VK, are reviewed.

摘要

维生素K(VK)因其在多种血液凝固因子合成中的作用而广为人知。VK也是骨代谢的一个重要因素,它通过对诸如骨钙素、基质Gla蛋白和蛋白S等VK依赖蛋白进行γ-羧化作用来实现。最近,严重VK缺乏的情况已较为罕见。然而,低膳食VK摄入量或低VK状态已被证明与低骨矿物质密度及髋部骨折风险增加有关。这些研究表明,即使在血液凝固的VK状态充足时,骨骼中仍可能存在潜在的VK不足。在本综述中,对有关血清VK浓度与骨骼健康之间关系的研究进行了综述,包括VK类似物(如叶绿醌和甲萘醌)的药代动力学以及影响VK血液循环的因素。

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