Okada Yosuke, Nawata Masao, Tanaka Yoshiya
University of Occupational and Environmental Health, School of Medicine, The First Department of Internal Medicine.
Clin Calcium. 2007 Nov;17(11):1762-8.
Rheumatoid arthritis (RA) is characterized by inflammatory synovitis, erosive arthritis and joint destruction. Recent evidence indicates that inflammatory cytokines such as TNF-alpha or IL-6 plays a pathological role in joint destruction and osteoporosis and that anti-cytokine therapy or anti-RANKL antibody provides significant protection against the process.
类风湿性关节炎（RA）的特征是炎症性滑膜炎、侵蚀性关节炎和关节破坏。最近的证据表明，诸如肿瘤坏死因子-α或白细胞介素-6等炎性细胞因子在关节破坏和骨质疏松症中起病理作用，并且抗细胞因子疗法或抗核因子κB受体活化因子配体（RANKL）抗体可对该过程提供显著保护。
