Okada Yosuke, Nawata Masao, Tanaka Yoshiya
The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health.
Clin Calcium. 2009 Aug;19(8):1186-90.
Rheumatoid arthritis (RA) is characterized by inflammatory synovitis, erosive arthritis and joint destruction. Recent evidence indicates that inflammatory cytokines such as TNF-alphaor IL-6 plays a pathological role in joint destruction and osteoporosis and that anti-cytokine therapy provides significant protection against the process. In this article, we described our findings that TNF-alphablocking therapy decreased urinary crosslinked N-telopeptide of type I collagen and increased serum bone alkaline phosphatase in RA patients.
类风湿关节炎（RA）的特征是炎症性滑膜炎、侵蚀性关节炎和关节破坏。最近的证据表明，诸如肿瘤坏死因子-α或白细胞介素-6等炎性细胞因子在关节破坏和骨质疏松中起病理作用，并且抗细胞因子疗法可对该过程提供显著保护。在本文中，我们描述了我们的研究发现，即肿瘤坏死因子-α阻断疗法可降低RA患者尿液中I型胶原交联N-端肽水平，并提高血清骨碱性磷酸酶水平。
