Moon Ju-young, Jeong Laeik, Lee Sangho, Jeong Kyunghwan, Lee Taewon, Ihm Chun-Gyoo, Suh Jungho, Kim Junghee, Jung Yoo-yeon, Chung Joo-Ho
Department of Nephrology, College of Medicine, Kyunghee University, Seoul, Korea.
J Korean Med Sci. 2007 Oct;22(5):810-4. doi: 10.3346/jkms.2007.22.5.810.
Monocyte chemoattractant protein-1 (MCP-1) is suggested to be involved in the progression of diabetic nephropathy. We investigated the association of the -2518 A/G polymorphism in the MCP-1 gene with progressive kidney failure in Korean patients with type 2 diabetes mellitus (DM). We investigated -2518 A/G polymorphism of the MCP-1 gene in type 2 DM patients with progressive kidney failure (n=112) compared with matched type 2 DM patients without nephropathy (diabetic control, n=112) and healthy controls (n=230). The overall genotypic distribution of -2518 A/G in the MCP-1 gene was not different in patients with type 2 DM compared to healthy controls. Although the genotype was not significantly different between the patients with kidney failure and the diabetic control (p=0.07), the A allele was more frequent in patients with kidney failure than in DM controls (42.0 vs. 32.1%, p=0.03). The carriage of A allele was significantly associated with kidney failure (68.8 vs. 54.5%, OR 1.84, 95% CI 1.07-3.18). In logistic regression analysis, carriage of A allele retained a significant association with diabetic kidney failure. Our result shows that the -2518 A allele of the MCP-1 gene is associated with kidney failure in Korean patients with type 2 DM.
单核细胞趋化蛋白-1（MCP-1）被认为与糖尿病肾病的进展有关。我们研究了韩国2型糖尿病（DM）患者中MCP-1基因-2518 A/G多态性与进行性肾衰竭的关联。我们调查了112例进行性肾衰竭的2型糖尿病患者、112例匹配的无肾病2型糖尿病患者（糖尿病对照组）和230例健康对照者的MCP-1基因-2518 A/G多态性。与健康对照相比，2型糖尿病患者中MCP-1基因-2518 A/G的总体基因型分布无差异。虽然肾衰竭患者与糖尿病对照组之间的基因型无显著差异（p=0.07），但肾衰竭患者中A等位基因的频率高于糖尿病对照组（42.0%对32.1%，p=0.03）。携带A等位基因与肾衰竭显著相关（68.8%对54.5%，OR 1.84，95%CI 1.07-3.18）。在逻辑回归分析中，携带A等位基因与糖尿病肾衰竭仍存在显著关联。我们的结果表明，MCP-1基因的-2518 A等位基因与韩国2型糖尿病患者的肾衰竭有关。
