Department of Endocrinology and Metabolism Disease, Bornova, Ege University Medical School, Izmir 35100, Turkey.
Endocrine. 2010 Jun;37(3):513-7. doi: 10.1007/s12020-010-9342-4. Epub 2010 Apr 21.
Tissue macrophage accumulation is thought to induce insulin resistance during obesity and stimulate the progression of diabetic nephropathy (DN). The objective of this study was to investigate genotypic and allelic frequencies of monocyte chemoattractant protein-1 (MCP-1) gene polymorphism in the healthy and patients with and without DN. The MCP-1 genotypes were determined in 43 patients with nephropathy and 43 without nephropathy and a control group of 105 healthy individuals. The genotype MCP-1 (-2518G/A) distribution did differ between the control group and the type 2 diabetic patients (P = 0.004). The frequency of the polymorphic G allele was also no similar for the group with type 2 diabetes as for the control group with 20.9 and 32.4%, respectively (P = 0.012). The AA genotype and A allele at MCP-1 -2518 was an independent risk factor for the progression of type 2 diabetes. In conclusion, MCP-1 AA genotype and A allele may play a specific role(s) in determining diabetic susceptibility, but do not seem to be important in the clinical manifestations of DN.
组织巨噬细胞积累被认为会在肥胖期间诱导胰岛素抵抗，并刺激糖尿病肾病 (DN) 的进展。本研究的目的是研究单核细胞趋化蛋白-1 (MCP-1) 基因多态性在健康人群、DN 患者和非 DN 患者中的基因型和等位基因频率。在 43 名肾病患者、43 名非肾病患者和 105 名健康对照者中确定了 MCP-1 基因型。MCP-1 (-2518G/A) 基因型在对照组和 2 型糖尿病患者之间存在差异 (P = 0.004)。多态性 G 等位基因在 2 型糖尿病组和对照组中的频率也不同，分别为 20.9%和 32.4% (P = 0.012)。MCP-1 -2518 的 AA 基因型和 A 等位基因是 2 型糖尿病进展的独立危险因素。总之，MCP-1 AA 基因型和 A 等位基因可能在决定糖尿病易感性方面发挥特定作用，但在 DN 的临床表现中似乎并不重要。
