Holmquist L, Stuchbury G, Steele M, Münch G
Department of Biochemistry and Molecular Biology, School of Pharmacy and Molecular Sciences, James Cook University, Townsville, Australia.
J Neural Transm Suppl. 2007(72):39-41. doi: 10.1007/978-3-211-73574-9_6.
Hydrogen peroxide has been shown to act as a second messenger mediating intracellular redox-sensitive signal transduction. Here we show that hydrogen peroxide is also able to transmit pro-inflammatory signals from one cell to the other and that this action can be inhibited by extracellularly added catalase. If these data can be further substantiated, hydrogen peroxide might become as important as nitric oxide as a small molecule intercellular (first) messenger.
过氧化氢已被证明可作为第二信使介导细胞内氧化还原敏感的信号转导。在此我们表明，过氧化氢还能够将促炎信号从一个细胞传递至另一个细胞，并且这种作用可被细胞外添加的过氧化氢酶抑制。如果这些数据能够得到进一步证实，那么过氧化氢可能会成为与一氧化氮同样重要的小分子细胞间（第一）信使。
