Apostu M, Dorneanu V, Bibire Nela
Facultatea de Farmacie, Disciplina de Chimie Analitică, Universitatea de Medicină si Farmacie "Gr.T. Pop" Iaşi.
Rev Med Chir Soc Med Nat Iasi. 2007 Apr-Jun;111(2):530-4.
Phosphotungstic acid forms salt type ionic association complexes with a large number of medicinal drugs that contain cation forming proton acceptor moieties.
Ranitidine, nizatidine and famotidine complexes with phosphotungstic acid were synthesized and subsequently characterized by their melting point, water solubility, specific absorbance, UV spectra and IR spectra.
These sparingly soluble complexes were applied for the fabrication of membrane selective electrodes for quantitative potentiometric determination of ranitidine, nizatidine and famotidine.
There have been synthesized phosphotungstic acid complexes with uses in fabrication of membrane selective electrodes for quantitative potentiometric determination of ranitidine, nizatidine and famotidine.
磷钨酸与大量含有形成阳离子的质子受体部分的药物形成盐型离子缔合络合物。
合成了雷尼替丁、尼扎替丁和法莫替丁与磷钨酸的络合物，随后通过熔点、水溶性、比吸光度、紫外光谱和红外光谱对其进行了表征。
这些微溶性络合物被用于制造膜选择性电极，用于雷尼替丁、尼扎替丁和法莫替丁的定量电位测定。
已合成了磷钨酸络合物，用于制造膜选择性电极，用于雷尼替丁、尼扎替丁和法莫替丁的定量电位测定。
