人类遗传学：全基因组关联研究的隐藏文本

Human genetics: the hidden text of genome-wide associations.

作者信息

Gibson Greg, Goldstein David B

机构信息

Department of Genetics, North Carolina State University, Gardner Hall, Raleigh, North Carolina 27695-7614, USA.

出版信息

Curr Biol. 2007 Nov 6;17(21):R929-32. doi: 10.1016/j.cub.2007.08.044.

DOI:10.1016/j.cub.2007.08.044

PMID:17983573

Abstract

Genome-wide association studies are finally leading geneticists straight to the genetic susceptibility factors for complex diseases. Several challenges lie ahead, including translation of the findings into practical public health outcomes, and integrating genetic analysis with broader biological understanding.

摘要

全基因组关联研究终于带领遗传学家直接找到了复杂疾病的遗传易感性因素。前方仍有若干挑战，包括将研究结果转化为实际的公共卫生成果，以及将遗传分析与更广泛的生物学理解相结合。