旅行相关的伯纳特柯克斯体感染：三例临床表现各异的Q热病例
Travel-associated Coxiella burnetii infections: three cases of Q fever with different clinical manifestation.
作者信息
Kobbe Robin, Kramme Stefanie, Gocht Andreas, Werner Mathias, Lippert Ute, May Jürgen, Burchard Gerd
机构信息
Infectious Disease Epidemiology, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Str 74, D-20359 Hamburg, Germany.
出版信息
Travel Med Infect Dis. 2007 Nov;5(6):374-9. doi: 10.1016/j.tmaid.2007.07.005. Epub 2007 Sep 12.
BACKGROUND
Certain activities expose travellers to Coxiella burnetii, the causative agent of acute human Q fever. Awareness of Q fever must be improved, also as a potential imported disease, but delayed seroconversion and serological cross-reactivity complicate the diagnosis. Granulomatous inflammation of liver and bone marrow can be typical histopathological findings.
CASE PRESENTATIONS
We present three imported cases of Q fever with different clinical presentations, in which the travel history identified the sources of infection.
CONCLUSIONS
Q fever should be suspected in any imported febrile disease of unknown origin. Clinical manifestations are variable and repeated serological testing is mandatory. In some cases diagnostic biopsies might help to establish early diagnosis.
背景
某些活动使旅行者接触到急性人类Q热的病原体——伯氏考克斯体。必须提高对Q热的认识，它也是一种潜在的输入性疾病，但血清转化延迟和血清学交叉反应使诊断变得复杂。肝脏和骨髓的肉芽肿性炎症可能是典型的组织病理学表现。
病例报告
我们报告了3例临床表现各异的输入性Q热病例，通过旅行史确定了感染源。
结论
对于任何不明原因的输入性发热疾病都应怀疑Q热。临床表现多样，必须反复进行血清学检测。在某些情况下，诊断性活检可能有助于早期诊断。
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