Haider Husnain K, Elmadbouh Ibrahim, Jean-Baptiste Michel, Ashraf Muhammad
Department of Pathology and Laboratory Medicine, University of Cincinnati, OH 45267-0529, USA.
Mol Med. 2008 Jan-Feb;14(1-2):79-86. doi: 10.2119/2007-00092.Haider.
Therapeutic angiogenesis and myogenesis restore perfusion of ischemic myocardium and improve left ventricular contractility. These therapeutic modalities must be considered as complementary rather than competing to exploit their advantages for optimal beneficial effects. The resistant nature of cardiomyocytes to gene transfection can be overcome by ex vivo delivery of therapeutic genes to the heart using genetically modified stem cells. This review article gives an overview of different vectors and delivery systems in general used for therapeutic gene delivery to the heart and provides a critical appreciation of the ex vivo gene delivery approach using genetically modified stem cells to achieve angiomyogenesis for the treatment of infarcted heart.
治疗性血管生成和肌生成可恢复缺血心肌的灌注并改善左心室收缩力。必须将这些治疗方式视为互补而非相互竞争的,以利用它们的优势获得最佳有益效果。通过使用基因修饰的干细胞将治疗基因离体递送至心脏,可以克服心肌细胞对基因转染的抗性。本文综述了一般用于向心脏进行治疗性基因递送的不同载体和递送系统,并对使用基因修饰的干细胞进行离体基因递送以实现血管肌生成治疗梗死心脏的方法进行了批判性评价。