The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Regen Med. 2010 Jan;5(1):121-43. doi: 10.2217/rme.09.74.
Stem cells have emerged as a key element of regenerative medicine therapies due to their inherent ability to differentiate into a variety of cell phenotypes, thereby providing numerous potential cell therapies to treat an array of degenerative diseases and traumatic injuries. A recent paradigm shift has emerged suggesting that the beneficial effects of stem cells may not be restricted to cell restoration alone, but also due to their transient paracrine actions. Stem cells can secrete potent combinations of trophic factors that modulate the molecular composition of the environment to evoke responses from resident cells. Based on this new insight, current research directions include efforts to elucidate, augment and harness stem cell paracrine mechanisms for tissue regeneration. This article discusses the existing studies on stem/progenitor cell trophic factor production, implications for tissue regeneration and cancer therapies, and development of novel strategies to use stem cell paracrine delivery for regenerative medicine.
干细胞因其具有分化为多种细胞表型的固有能力，从而为治疗多种退行性疾病和创伤性损伤提供了众多潜在的细胞疗法，因此成为再生医学治疗的关键因素。最近出现了一种新的模式转变，表明干细胞的有益作用不仅限于细胞修复，还归因于其短暂的旁分泌作用。干细胞可以分泌出有效的营养因子组合，调节环境的分子组成，从而引发驻留细胞的反应。基于这一新的认识，目前的研究方向包括努力阐明、增强和利用干细胞旁分泌机制进行组织再生。本文讨论了关于干细胞/祖细胞营养因子产生的现有研究、对组织再生和癌症治疗的影响，以及开发利用干细胞旁分泌递送来进行再生医学的新策略。
