Tanaka Eiji, Detamore Michael S, Tanimoto Kotaro, Kawai Nobuhiko
Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan.
Ann Biomed Eng. 2008 Jan;36(1):14-29. doi: 10.1007/s10439-007-9401-z. Epub 2007 Nov 6.
Although tissue engineering of the temporomandibular joint (TMJ) structures is in its infancy, tissue engineering provides the revolutionary possibility for treatment of temporomandibular disorders (TMDs). Recently, several reviews have provided a summary of knowledge of TMJ structure and function at the biochemical, cellular, or mechanical level for tissue engineering of mandibular cartilage, bone and the TMJ disc. As the TMJ enables large relative movements, joint lubrication can be considered of great importance for an understanding of the dynamics of the TMJ. The tribological characteristics of the TMJ are essential for reconstruction and tissue engineering of the joint. The purpose of this review is to provide a summary of advances relevant to the tribological characteristics of the TMJ and to serve as a reference for future research in this field. This review consists of four parts. Part 1 is a brief review of the anatomy and function of the TMJ articular components. In Part 2, the biomechanical and biochemical factors associated with joint lubrication are described: the articular surface topology with microscopic surface roughness and the biomechanical loading during jaw movements. Part 3 includes lubrication theories and possible mechanisms for breakdown of joint lubrication. Finally, in Part 4, the requirement and possibility of tissue engineering for treatment of TMDs with degenerative changes as a future treatment regimen will be discussed in a tribological context.
尽管颞下颌关节（TMJ）结构的组织工程尚处于起步阶段，但组织工程为颞下颌关节紊乱病（TMDs）的治疗提供了革命性的可能性。最近，几篇综述总结了下颌软骨、骨和TMJ盘组织工程在生化、细胞或力学水平上的TMJ结构和功能知识。由于TMJ能进行大幅度的相对运动，关节润滑对于理解TMJ的动力学至关重要。TMJ的摩擦学特性对于关节的重建和组织工程至关重要。本综述的目的是总结与TMJ摩擦学特性相关的进展，并为该领域的未来研究提供参考。本综述共分为四个部分。第一部分简要回顾了TMJ关节组件的解剖结构和功能。在第二部分中，描述了与关节润滑相关的生物力学和生化因素：具有微观表面粗糙度的关节表面拓扑结构以及下颌运动过程中的生物力学负荷。第三部分包括润滑理论和关节润滑失效的可能机制。最后，在第四部分中，将在摩擦学背景下讨论以组织工程作为未来治疗方案治疗具有退行性改变的TMDs的要求和可能性。
