Chen Wen, Ye Qianwen, Zhang Mingshuo, Xie Renjian, Xu Chunming
School of Rehabilitation Medicine, Gannan Medical University, Ganzhou 341000, China.
Jiangxi Provincial Key Laboratory of Tissue Engineering (2024SSY06291), Gannan Medical University, Ganzhou 341000, China.
Int J Mol Sci. 2025 Feb 21;26(5):1856. doi: 10.3390/ijms26051856.
Osteoarthritis (OA) is a common degenerative joint disease that progressively destroys articular cartilage, leading to increased joint friction and severe pain. Therefore, OA can be treated by restoring the lubricating properties of cartilage. In this study, recent advances in lubricants for the treatment of OA are reviewed for both single-function and multifunctional lubricants. Single-function lubricants mainly include glycosaminoglycans, lubricin, and phospholipids, whereas multifunctional lubricants are composed of lubricating and anti-inflammatory bifunctional hydrogels, stem cell-loaded lubricating hydrogels, and drug-loaded lubricating nanoparticles. This review emphasizes the importance of restoring joint lubrication capacity for the treatment of OA and explores the structural features, lubrication properties, and role of these lubricants in modulating intracellular inflammatory responses and metabolism. Current challenges and future research directions in this field are also discussed, with the aim of providing a scientific basis and new ideas for the clinical treatment of OA.
骨关节炎（OA）是一种常见的退行性关节疾病，它会逐渐破坏关节软骨，导致关节摩擦增加和剧痛。因此，OA可通过恢复软骨的润滑特性来治疗。在本研究中，对用于治疗OA的润滑剂（包括单功能和多功能润滑剂）的最新进展进行了综述。单功能润滑剂主要包括糖胺聚糖、润滑素和磷脂，而多功能润滑剂则由具有润滑和抗炎双功能的水凝胶、负载干细胞的润滑水凝胶以及负载药物的润滑纳米颗粒组成。本综述强调了恢复关节润滑能力对OA治疗的重要性，并探讨了这些润滑剂的结构特征、润滑特性以及它们在调节细胞内炎症反应和代谢中的作用。还讨论了该领域当前面临的挑战和未来的研究方向，旨在为OA的临床治疗提供科学依据和新思路。
