阿尔茨海默病：脂质关联
Alzheimer's disease: the lipid connection.
作者信息
Hartmann Tobias, Kuchenbecker Johannna, Grimm Marcus O W
机构信息
Universität des Saarlandes, Uniklinikum Homburg, Neurobiologie, Homburg, Germany.
出版信息
J Neurochem. 2007 Nov;103 Suppl 1:159-70. doi: 10.1111/j.1471-4159.2007.04715.x.
Abstract
Alzheimer's disease is the most common neurodegenerative disorder. This short review summarizes the current knowledge about the role of lipids, especially cholesterol, sphingolipids, plasmalogens, and polyunsaturated fatty acids in Alzheimer's disease etiology, pathogenesis, risk-factors, prevention, treatment, and the function of the amyloid precursor protein and the amyloid peptides in lipid homeostasis.
摘要
阿尔茨海默病是最常见的神经退行性疾病。这篇简短综述总结了目前关于脂质，尤其是胆固醇、鞘脂、缩醛磷脂和多不饱和脂肪酸在阿尔茨海默病病因、发病机制、风险因素、预防、治疗中的作用，以及淀粉样前体蛋白和淀粉样肽在脂质稳态中的功能的相关知识。
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