一名多发性硬化症患者在接受米托蒽醌治疗后发生慢性髓性白血病。
Chronic myeloid leukemia associated with mitoxantrone treatment in a patient with MS.
作者信息
Sadiq Saud A, Rammal Mustapha, Sara Gabriel
机构信息
Division of Hematology/Oncology, Department of Medicine, St. Luke's - Roosevelt Hospital, New York, NY, USA.
出版信息
Mult Scler. 2008 Mar;14(2):272-3. doi: 10.1177/1352458507082941. Epub 2007 Nov 6.
We report the first case of chronic myeloid leukemia (CML) in a patient with multiple sclerosis (MS) diagnosed within two years of receiving mitoxantrone therapy. Previously only acute forms of leukemia particularly acute promyelocytic leukemia (APL) have been associated with mitoxantrone treatment in MS. This underscores the need for only using mitoxantrone in severe treatment-unresponsive cases of MS.
我们报告了首例在接受米托蒽醌治疗两年内被诊断出患有多发性硬化症（MS）的慢性粒细胞白血病（CML）患者。此前，在MS患者中，只有急性白血病形式，特别是急性早幼粒细胞白血病（APL）与米托蒽醌治疗有关。这突出表明仅在MS严重治疗无反应的病例中使用米托蒽醌的必要性。
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