Madhavarao S S, Trivedi K N
Department of Chemistry, Faculty of Science, M.S. University of Baroda, India.
Pharmazie. 1991 Sep;46(9):644-6.
Bromination of 2,7-dimethylfuro[2,3-h]benzopyran-5[H]-one (1a) and 2,5-dimethylfuro[3,2-g]benzopyran-7[H]-one (2a) with N-bromosuccinimide gave 2-bromomethyl-7-methylfuro[2,3-h]benzopyran-5[H]-one (1b) and 2-bromomethyl-5-methylfuro[3,2-g]benzopyran-7[H]-one (2b), respectively. The derivatives 1b and 2b were converted to 2-aminomethyl derivatives 1 c-h and 2 c-f by treatment with the appropriate secondary amine. The structures of 2-bromomethyl derivatives 1b and 2b have been confirmed by 13C-NMR spectra.
用N-溴代琥珀酰亚胺对2,7-二甲基呋喃并[2,3-h]苯并吡喃-5[H]-酮（1a）和2,5-二甲基呋喃并[3,2-g]苯并吡喃-7[H]-酮（2a）进行溴化反应，分别得到2-溴甲基-7-甲基呋喃并[2,3-h]苯并吡喃-5[H]-酮（1b）和2-溴甲基-5-甲基呋喃并[3,2-g]苯并吡喃-7[H]-酮（2b）。通过用适当的仲胺处理，衍生物1b和2b被转化为2-氨甲基衍生物1c-h和2c-f。2-溴甲基衍生物1b和2b的结构已通过13C-NMR光谱得到证实。
