Pagni F
Dipartimento di Scienze Chirurgiche Università di Milano "Bicocca", U.O. Anatomia Patologica, Ospedale Civile di Vimercate, Presidio di Desio, Italy.
Pathologica. 2007 Jun;99(3):84-6.
Cutaneous inflammatory pseudotumor is a rare benign condition that should be macroscopically differentiated, from dermatofibroma and metastases of carcinoma and, histologically from cutaneous lymphomas and other more aggressive diseases. We report herein the case of a 63-year-old man with a painless nodule of the left arm skin with a rapid growth (1 month ago). The histological examination revealed a well-defined dermal nodule of plasmacytoid cells, without connection or infiltration of the epidermis. At high power the polymorphous cellular infiltrate was, constituted by medium- small elements with widespread features of lympho-plasmocytoid differentiation or clear plasmacellular features. Immunohistochemical analysis showed a polyclonal cytological pattern with expression of both immunoglobulin light chains kappa e lambda by plasmacytoid and admixed B and T lymphocytes. The final diagnosis was Plasmocytoid granuloma an entity that is recognized within the so called "Cutaneous inflammatory pseudotumor" together with the myofibroblastic tumor.
皮肤炎性假瘤是一种罕见的良性疾病,在宏观上应与皮肤纤维瘤、癌转移相鉴别,在组织学上应与皮肤淋巴瘤及其他侵袭性更强的疾病相鉴别。我们在此报告一例63岁男性病例,其左臂皮肤出现一个无痛性结节,生长迅速(1个月前)。组织学检查显示真皮内有一个界限清楚的浆细胞样细胞结节,与表皮无连接或浸润。高倍镜下,多形性细胞浸润由中等大小的细胞组成,具有广泛的淋巴浆细胞样分化特征或明显的浆细胞特征。免疫组化分析显示多克隆细胞学模式,浆细胞样细胞以及混合的B和T淋巴细胞均表达免疫球蛋白轻链κ和λ。最终诊断为浆细胞样肉芽肿,这是一种在所谓的“皮肤炎性假瘤”中与肌成纤维细胞瘤一同被认可的实体。