碳青霉烯类普拉特烯霉素的全合成及其抗菌性能
Total synthesis and antibacterial properties of carbaplatensimycin.
作者信息
Nicolaou K C, Tang Yefeng, Wang Jianhua, Stepan Antonia F, Li Ang, Montero Ana
机构信息
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
出版信息
J Am Chem Soc. 2007 Dec 5;129(48):14850-1. doi: 10.1021/ja076126e. Epub 2007 Nov 8.
The chemical synthesis and biological evaluation of carbaplatensimycin, the carbon analogue of the recently reported antibiotic platensimycin has been accomplished. Carbaplatensimycin exhibited similar potency to the natural product as an antibacterial agent against a variety of strains, including methicilin- and vancomycin-resistant bacteria.
最近报道的抗生素普拉特链霉菌素的碳类似物碳普拉特链霉菌素的化学合成及生物学评价已经完成。作为一种抗菌剂，碳普拉特链霉菌素对包括耐甲氧西林和耐万古霉素细菌在内的多种菌株显示出与天然产物相似的效力。
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