异普拉替尼霉素：合成与生物学评价。
Isoplatensimycin: Synthesis and biological evaluation.
作者信息
Jang Ki Po, Kim Chan Hyuk, Na Seong Wook, Kim Hiyoung, Kang Heonjoong, Lee Eun
机构信息
Department of Chemistry, College of Natural Sciences, Seoul National University, Seoul 151-747, Republic of Korea.
出版信息
Bioorg Med Chem Lett. 2009 Aug 15;19(16):4601-2. doi: 10.1016/j.bmcl.2009.06.092. Epub 2009 Jun 27.
PMID:19604693
Abstract
Isoplatensimycin, a novel analog of platensimycin, was synthesized via intramolecular dipolar cycloaddition of a carbonyl ylide. Isoplatensimycin showed little activities against strains of Staphylococcus aureus, but exhibited activities against some vancomycin-resistant enteroccoci.
摘要
异普拉特烯霉素是普拉特烯霉素的一种新型类似物，通过羰基叶立德的分子内偶极环加成反应合成。异普拉特烯霉素对金黄色葡萄球菌菌株几乎没有活性，但对一些耐万古霉素肠球菌具有活性。
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