Department of Chemistry, College of Natural Sciences, Seoul National University, Seoul 151-747, Republic of Korea.
Bioorg Med Chem Lett. 2010 Apr 1;20(7):2156-8. doi: 10.1016/j.bmcl.2010.02.037. Epub 2010 Feb 13.
Carbonyl ylide cycloaddition strategy was employed in the synthesis of platensimycin analogs. 7-Phenylplatensimycin and 11-methyl-7-phenylplatensimycin are more potent analogs of platensimycin.
采用羰基叶立德环加成策略合成了普那霉素类似物。7-苯基普那霉素和 11-甲基-7-苯基普那霉素是普那霉素更有效的类似物。