Kumar Rajendran Senthil, Arunachalam Sankaralingam, Periasamy Vaiyapuri Subbarayan, Preethy Christo Paul, Riyasdeen Anvarbatcha, Akbarsha Mohammad Abdulkader
Department of Chemistry, Bharathidasan University, Palkalaiperur, Tiruchirappalli 620 024, Tamil Nadu, India.
Eur J Med Chem. 2008 Oct;43(10):2082-91. doi: 10.1016/j.ejmech.2007.09.017. Epub 2007 Sep 29.
Some novel water-soluble polymer-copper(II)-phenanthroline complex samples, [Cu(phen)2(BPEI)]Cl(2).4H2O (phen=1,10-phenanthroline, BPEI=branched polyethyleneimine), with different degrees of copper complex content in the polymer chain have been prepared by ligand substitution method in water-ethanol medium and characterized by infrared, UV-visible, EPR spectral and elemental analysis methods. The binding of these complex samples with DNA has been investigated by electronic absorption spectroscopy, emission spectroscopy and gel retardation assay. Electrostatic interactions between DNA molecule and polymer-copper(II) complex molecule containing many high positive charges have been observed. Besides these ionic interactions, van der Waals interactions, hydrogen bonding and other partial intercalation binding modes may also exist in this system. The polymer-copper(II) complex with higher degree of copper complex content was screened for its antimicrobial activity and antitumor activity.
通过配体取代法在水 - 乙醇介质中制备了一些新型水溶性聚合物 - 铜（II）- 菲咯啉配合物样品，[Cu(phen)₂(BPEI)]Cl₂·4H₂O（phen = 1,10 - 菲咯啉，BPEI = 支化聚乙烯亚胺），聚合物链中铜配合物含量不同，并通过红外、紫外可见、电子顺磁共振光谱和元素分析方法进行了表征。通过电子吸收光谱、发射光谱和凝胶阻滞试验研究了这些配合物样品与DNA的结合情况。观察到DNA分子与含有许多高正电荷的聚合物 - 铜（II）配合物分子之间的静电相互作用。除了这些离子相互作用外，该体系中还可能存在范德华相互作用、氢键和其他部分插入结合模式。筛选了铜配合物含量较高的聚合物 - 铜（II）配合物的抗菌活性和抗肿瘤活性。
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