Bautista Arjel D, Craig Cody J, Harker Elizabeth A, Schepartz Alanna
Department of Chemistry, Yale University, New Haven, CT 06520, USA.
Curr Opin Chem Biol. 2007 Dec;11(6):685-92. doi: 10.1016/j.cbpa.2007.09.009. Epub 2007 Nov 7.
Advances in the foldamer field in recent years are as diverse as the backbones of which they are composed. Applications have ranged from cellular penetration and membrane disruption to discrete molecular recognition, while efforts to control the complex geometric shape of foldamers has entered the realm of tertiary and quaternary structure. This review will provide recent examples of progress in the foldamer field, highlighting the significance of this class of compounds and the advances that have been made towards exploiting their full potential.
近年来,折叠体领域的进展与其所构成的主链一样多样。其应用范围涵盖了从细胞穿透和膜破坏到离散分子识别,而控制折叠体复杂几何形状的努力已进入三级和四级结构领域。本综述将提供折叠体领域近期进展的实例,突出这类化合物的重要性以及在充分发挥其潜力方面所取得的进展。