Silverman Heather G, Roberto Francisco F
Biological Systems Department, Idaho National Laboratory, Idaho Falls, Idaho 83415, USA.
Mar Biotechnol (NY). 2007 Nov-Dec;9(6):661-81. doi: 10.1007/s10126-007-9053-x. Epub 2007 Nov 8.
In addition to identifying the proteins that have a role in underwater adhesion by marine mussels, research efforts have focused on identifying the genes responsible for the adhesive proteins, environmental factors that may influence protein production, and strategies for producing natural adhesives similar to the native mussel adhesive proteins. The production-scale availability of recombinant mussel adhesive proteins will enable researchers to formulate adhesives that are water-impervious and ecologically safe and can bind materials ranging from glass, plastics, metals, and wood to materials, such as bone or teeth, biological organisms, and other chemicals or molecules. Unfortunately, as of yet scientists have been unable to duplicate the processes that marine mussels use to create adhesive structures. This study provides a background on adhesive proteins identified in the blue mussel, Mytilus edulis, and introduces our research interests and discusses the future for continued research related to mussel adhesion.
除了鉴定在海洋贻贝水下黏附中发挥作用的蛋白质外,研究工作还集中在鉴定负责黏附蛋白的基因、可能影响蛋白质产生的环境因素,以及生产与天然贻贝黏附蛋白相似的天然黏合剂的策略。重组贻贝黏附蛋白的规模化生产将使研究人员能够配制出防水且生态安全的黏合剂,这些黏合剂能够黏合从玻璃、塑料、金属和木材到诸如骨骼或牙齿、生物有机体以及其他化学物质或分子等各种材料。不幸的是,到目前为止,科学家们还无法复制海洋贻贝用于形成黏附结构的过程。本研究提供了在蓝贻贝(紫贻贝)中鉴定出的黏附蛋白的背景信息,并介绍了我们的研究兴趣,还讨论了与贻贝黏附相关的持续研究的未来。