探索天然人类抗体库以开发抗病毒疗法。
Exploring the native human antibody repertoire to create antiviral therapeutics.
作者信息
Dessain S K, Adekar S P, Berry J D
机构信息
Cardeza Foundation for Hematologic Research, Kimmel Cancer Center, Thomas Jefferson University, Curtis Building 812, 1015 Walnut St., Philadelphia, PA 19107, USA.
出版信息
Curr Top Microbiol Immunol. 2008;317:155-83. doi: 10.1007/978-3-540-72146-8_6.
Native human antibodies are defined as those that arise naturally as the result of the functioning of an intact human immune system. The utility of native antibodies for the treatment of human viral diseases has been established through experience with hyperimmune human globulins. Native antibodies, as a class, differ in some respects from those obtained by recombinant library methods (phage or transgenic mouse) and possess distinct properties that may make them ideal therapeutics for human viral diseases. Methods for cloning native human antibodies have been beset by technical problems, yet many antibodies specific for viral antigens have been cloned. In the present review, we discuss native human antibodies and ongoing improvements in cloning methods that should facilitate the creation of novel, potent antiviral therapeutics obtained from the native human antibody repertoire.
天然人类抗体被定义为那些因完整人类免疫系统发挥功能而自然产生的抗体。通过对超免疫人球蛋白的研究经验，已证实天然抗体在治疗人类病毒性疾病方面的效用。作为一个类别，天然抗体在某些方面与通过重组文库方法（噬菌体或转基因小鼠）获得的抗体不同，并且具有独特的特性，这可能使它们成为治疗人类病毒性疾病的理想疗法。克隆天然人类抗体的方法一直受到技术问题的困扰，但许多针对病毒抗原的抗体已被克隆出来。在本综述中，我们讨论了天然人类抗体以及克隆方法的不断改进，这些改进应有助于从天然人类抗体库中开发出新型、有效的抗病毒疗法。
Zotero 插件