Tsutsumi Hiroyuki
Department of Pediatrics, Sapporo Medical University School of Medicine.
Nihon Rinsho. 2002 Mar;60(3):585-90.
Viral infections, particularly in the fetus or newborn and in immunocompromised individuals, can produce severe, even fatal disease. Indeed Herpesviridae infections are the major cause of morbidity and mortality in them. Antiviral drugs have been used for prophylaxis and treatment for some viral infections. An alternative approach is to boost the host immune defences. Administration of pooled human sera have been used for prophylaxis or alleviation of clinical severity of ongoing infections with measles, CMV, VZV and hepatitis A and B and so on. Human monoclonal antibody preparations, which have now being developed, may overcome the problems inherent in the pooled sera. These include high volume load, difficulty of quality control and adventitious transmission of unknown pathogenic agents.
病毒感染，尤其是在胎儿、新生儿以及免疫功能低下的个体中，可引发严重甚至致命的疾病。事实上，疱疹病毒科感染是这些人群发病和死亡的主要原因。抗病毒药物已被用于某些病毒感染的预防和治疗。另一种方法是增强宿主的免疫防御。静脉注射人免疫球蛋白已被用于预防或减轻麻疹、巨细胞病毒、水痘带状疱疹病毒以及甲型和乙型肝炎等正在进行的感染的临床严重程度。目前正在研发的人单克隆抗体制剂可能会克服静脉注射人免疫球蛋白中固有的问题。这些问题包括高容量负荷、质量控制困难以及未知病原体的偶然传播。
