Melegh Zsombor, Patel Yatin, Ramani Pramila
Department of Histopathology, Bristol Royal Infirmary, Marlborough Street, Bristol, BS2 8HW, United Kingdom.
Pediatr Dev Pathol. 2008 Nov-Dec;11(6):465-8. doi: 10.2350/07-03-0249.1. Epub 2007 Jun 13.
Pulmonary infantile hemangiomas are extremely rare in infancy and childhood. We describe a case of a 22-month-old infant who presented with repeated chest infections. Imaging studies revealed a solitary parenchymal lung lesion in the left upper lobe, an atrial septal defect, and mild right ventricular dilatation. Various investigations failed to delineate the precise nature of the lung lesion and it was resected. Histological examination of the lung lesion showed an infantile hemangioma, which expressed glucose transporter-1 protein, GLUT-1, a marker of infantile hemangiomas. This case represents a unique coexistence of 2 lesions, both of which resulted in right-sided overload, contributed to mainly by the atrial septal defect causing increased volume and, to a lesser extent, by the pulmonary hemangioma resulting in increased pressure. This case also emphasizes the fact that infantile hemangioma, although rare, should be considered as a differential diagnosis of solitary lung lesions.
肺婴儿血管瘤在婴儿期和儿童期极为罕见。我们描述了一例22个月大的婴儿，该婴儿反复出现胸部感染。影像学检查显示左上叶有一个孤立的实质性肺病变、房间隔缺损和轻度右心室扩张。各种检查未能明确肺病变的确切性质，遂将其切除。肺病变的组织学检查显示为婴儿血管瘤，其表达葡萄糖转运蛋白-1（GLUT-1），这是婴儿血管瘤的一个标志物。该病例代表了两种病变的独特共存，这两种病变均导致右侧负荷过重，主要是由房间隔缺损导致容量增加引起的，而在较小程度上是由肺血管瘤导致压力增加引起的。该病例还强调了这样一个事实，即婴儿血管瘤虽然罕见，但应被视为孤立性肺病变的鉴别诊断之一。
