Hsu Shih-Ping, Wu Ming-Shiou, Yang Chih-Ching, Huang Kuo-Chin, Liou Shaw-Yih, Hsu Su-Ming, Chien Chiang-Ting
Institute of Clinical Research, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan.
Am J Clin Nutr. 2007 Nov;86(5):1539-47. doi: 10.1093/ajcn/86.5.1539.
Oxidative stress increases in patients with end-stage renal disease and exaggerates the related comorbidities.
The aim of the study was to evaluate the effects of supplementation with decaffeinated green tea extract (catechins) on hemodialysis-induced reactive oxygen species, atherosclerotic disease risk factors, and proinflammatory cytokines.
We enrolled 6 healthy subjects and 54 hemodialysis patients for the study. First, the pharmacokinetics of one oral dose of catechins was compared between healthy subjects (n = 6) and hemodialysis patients (n = 10). Second, in the 10 hemodialysis patients, we compared the antioxidant effects of 3 different doses (0, 455, and 910 mg) of oral catechins with that of oral vitamin C (500 mg) during a hemodialysis session. Third, the other 44 hemodialysis patients participated in a 7-mo interventional study, in which 30 patients received placebo throughout and 14 patients received catechins (455 mg/d) from the third to the fifth month.
After one oral dose, the hemodialysis patients (n = 10) had later peaks and slower decay of plasma catechins than did the healthy subjects. In the 10 hemodialysis patients, catechin supplementation reduced hemodialysis-enhanced plasma hypochlorous acid activity more effectively than did placebo or vitamin C. Between treatments with 455 or 910 mg catechins, no significant difference was found in the reduction of plasma hypochlorous acid activity. Catechins also significantly reduced proinflammatory cytokine expression enhanced by hemodialysis. In the 7-mo interventional study, the 14 patients who received daily supplementation of catechins for 3 mo had less predialysis plasma hydrogen peroxide activity, lower hypochlorous acid activity, and lower phosphatidylcholine hydroperoxide, C-reactive protein, and proinflammatory cytokine concentrations than did the 30 hemodialysis patients who received placebo.
Catechins reduce hemodialysis-induced production of hydrogen peroxide and hypochlorous acid, atherosclerotic disease risk factors, and proinflammation.
终末期肾病患者的氧化应激增加，并加剧相关合并症。
本研究旨在评估补充脱咖啡因绿茶提取物（儿茶素）对血液透析诱导的活性氧、动脉粥样硬化疾病危险因素和促炎细胞因子的影响。
我们招募了6名健康受试者和54名血液透析患者进行研究。首先，比较了6名健康受试者（n = 6）和10名血液透析患者口服一剂儿茶素后的药代动力学。其次，在10名血液透析患者中，我们比较了3种不同剂量（0、455和910 mg）的口服儿茶素与口服维生素C（500 mg）在一次血液透析过程中的抗氧化作用。第三，另外44名血液透析患者参与了一项为期7个月的干预研究，其中30名患者全程接受安慰剂，14名患者从第三个月到第五个月接受儿茶素（455 mg/d）。
口服一剂后，血液透析患者（n = 10）血浆儿茶素的峰值出现较晚且衰减较慢，而健康受试者则不然。在10名血液透析患者中，补充儿茶素比安慰剂或维生素C更有效地降低了血液透析增强的血浆次氯酸活性。在使用455或910 mg儿茶素治疗之间，血浆次氯酸活性的降低没有显著差异。儿茶素还显著降低了血液透析增强的促炎细胞因子表达。在为期7个月的干预研究中，14名每天补充儿茶素3个月的患者在透析前的血浆过氧化氢活性、次氯酸活性以及磷脂酰胆碱过氧化氢、C反应蛋白和促炎细胞因子浓度均低于30名接受安慰剂的血液透析患者。
儿茶素可减少血液透析诱导的过氧化氢和次氯酸生成、动脉粥样硬化疾病危险因素以及促炎反应。
