Griffiths-Jones Sam, Saini Harpreet Kaur, van Dongen Stijn, Enright Anton J
Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester, UK.
Nucleic Acids Res. 2008 Jan;36(Database issue):D154-8. doi: 10.1093/nar/gkm952. Epub 2007 Nov 8.
miRBase is the central online repository for microRNA (miRNA) nomenclature, sequence data, annotation and target prediction. The current release (10.0) contains 5071 miRNA loci from 58 species, expressing 5922 distinct mature miRNA sequences: a growth of over 2000 sequences in the past 2 years. miRBase provides a range of data to facilitate studies of miRNA genomics: all miRNAs are mapped to their genomic coordinates. Clusters of miRNA sequences in the genome are highlighted, and can be defined and retrieved with any inter-miRNA distance. The overlap of miRNA sequences with annotated transcripts, both protein- and non-coding, are described. Finally, graphical views of the locations of a wide range of genomic features in model organisms allow for the first time the prediction of the likely boundaries of many miRNA primary transcripts. miRBase is available at http://microrna.sanger.ac.uk/.
miRBase是微小RNA（miRNA）命名法、序列数据、注释及靶标预测的核心在线数据库。当前版本（10.0）包含来自58个物种的5071个miRNA基因座，表达5922个不同的成熟miRNA序列：在过去两年里序列增长超过2000个。miRBase提供一系列数据以促进miRNA基因组学研究：所有miRNA都被定位到它们的基因组坐标。基因组中的miRNA序列簇被突出显示，并且可以用任意miRNA间距离来定义和检索。描述了miRNA序列与注释转录本（包括蛋白质编码和非编码转录本）的重叠情况。最后，模式生物中多种基因组特征位置的图形视图首次使得预测许多miRNA初级转录本的可能边界成为可能。可通过http://microrna.sanger.ac.uk/访问miRBase。
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