Cilliler Asli Ece, Ozturk Serefnur, Ozbakir Senay
1st Department of Neurology, Ankara Numune Education and Research Hospital, Ankara, Turkey.
Gerontology. 2007;53(6):419-22. doi: 10.1159/000110873. Epub 2007 Nov 8.
Recent studies suggest that magnesium, which specially affects the N-methyl-D-aspartate receptor response to excitatory amino acids, may be a supportive therapeutic agent in Alzheimer's disease.
To investigate the relationship between magnesium levels and the cognitive test results and clinical stages of the patients.
Thirty-seven patients (20 women, 17 men) and 34 controls were included in the study. The patients were staged according to Global Deterioration Scale (GDS) and Clinical Dementia Rating (CDR).
There was a significant difference for Mg levels according to GDS (p = 0.030). Similarly, Mg levels were different between patients with low and high CDR stages (p = 0.003). Mg levels were lower in the group whose MMSE scores were <20 than in those whose MMSE scores were >/=20. A negative correlation was found between Mg levels and GDS and CDR (respectively: r = -0.35, p = 0.033; r = -0.360, p = 0.029).
Our data suggest that there is a relationship between serum Mg levels and the degree of Alzheimer's disease and that the determination of the Mg level at various stages may provide valuable information in further understanding the progression and treatment of Alzheimer's disease.
近期研究表明，镁对N-甲基-D-天冬氨酸受体对兴奋性氨基酸的反应有特殊影响，可能是治疗阿尔茨海默病的一种辅助治疗药物。
探讨镁水平与患者认知测试结果及临床分期之间的关系。
本研究纳入37例患者（20例女性，17例男性）和34例对照。根据总体衰退量表（GDS）和临床痴呆评定量表（CDR）对患者进行分期。
根据GDS，镁水平存在显著差异（p = 0.030）。同样，低CDR分期和高CDR分期患者的镁水平也不同（p = 0.003）。简易精神状态检查表（MMSE）评分<20分的组的镁水平低于MMSE评分≥20分的组。镁水平与GDS和CDR之间存在负相关（分别为：r = -0.35，p = 0.033；r = -0.360，p = 0.029）。
我们的数据表明，血清镁水平与阿尔茨海默病的程度之间存在关联，在不同阶段测定镁水平可能为进一步了解阿尔茨海默病的进展和治疗提供有价值的信息。
