Park Young-Min, Che Hee-Jae, Im Chang-Hwan, Jung Hyung-Tae, Bae Sung-Man, Lee Seung-Hwan
Department of Neuropsychiatry, Inje University Ilsan Paik Hospital, Ilsansu-Ku, Goyang, South Korea.
Neurosci Res. 2008 Oct;62(2):112-7. doi: 10.1016/j.neures.2008.06.009. Epub 2008 Jul 10.
Global field synchronization (GFS) has recently been introduced to measure functional synchronization in frequency-domain EEG data. This study explored GFS values and its clinical significance in patients with Alzheimer's disease (AD).
EEGs were recorded from 22 AD patients and 23 age-matched healthy controls. GFS values were computed in the delta, theta, alpha, beta1, beta2, beta3, gamma, and full frequency bands. The Mini-Mental Status Examination (MMSE) and the Clinical Dementia Rating scale (CDR) were used to assess the symptom severity in AD patients.
GFS values in the beta1, beta2, beta3, and full bands were lower in AD patients than in healthy controls. GFS values in the alpha, beta1, beta2, beta3, and full bands were positively correlated with the MMSE and CDR scores in combined group (AD patients and healthy controls). In AD patients, GFS values were positively correlated with MMSE scores in the beta1, beta 3, and full bands, and with CDR scores in the delta band.
GFS values were significantly lower in AD patients than in healthy controls, and they were positively correlated with MMSE and CDR scores. Our results suggest that GFS values are a useful biological correlate of cognitive decline in AD patients.
全球场同步化（GFS）最近被引入用于测量频域脑电图（EEG）数据中的功能同步性。本研究探讨了阿尔茨海默病（AD）患者的GFS值及其临床意义。
记录了22例AD患者和23例年龄匹配的健康对照者的脑电图。计算了δ、θ、α、β1、β2、β3、γ和全频段的GFS值。使用简易精神状态检查表（MMSE）和临床痴呆评定量表（CDR）评估AD患者的症状严重程度。
AD患者β1、β2、β3和全频段的GFS值低于健康对照者。联合组（AD患者和健康对照者）中，α、β1、β2、β3和全频段的GFS值与MMSE和CDR评分呈正相关。在AD患者中，β1、β3和全频段的GFS值与MMSE评分呈正相关，δ频段的GFS值与CDR评分呈正相关。
AD患者的GFS值显著低于健康对照者，且与MMSE和CDR评分呈正相关。我们的结果表明，GFS值是AD患者认知功能下降的一个有用的生物学相关指标。
