过渡金属配合物作为抗癌和抗HIV药物的一些用途。
Some uses of transition metal complexes as anti-cancer and anti-HIV agents.
作者信息
Sun Raymond Wai-Yin, Ma Dik-Lung, Wong Ella Lai-Ming, Che Chi-Ming
机构信息
Department of Chemistry, Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, China.
出版信息
Dalton Trans. 2007 Nov 21(43):4884-92. doi: 10.1039/b705079h. Epub 2007 Sep 18.
The success of the clinical uses of cisplatin, cis-[Pt(II)(NH(3))(2)Cl(2)], has stimulated considerable interest in using other metal complexes as new therapeutic agents. This perspective describes our recent work on several classes of gold(III), platinum(II), ruthenium(II, III, IV), iron(II) and vanadium(IV) complexes for anti-cancer and anti-HIV treatments.
顺铂（顺式-[Pt(II)(NH₃)₂Cl₂]）临床应用的成功激发了人们对使用其他金属配合物作为新型治疗药物的浓厚兴趣。这篇综述介绍了我们最近在几类金(III)、铂(II)、钌(II、III、IV)、铁(II)和钒(IV)配合物用于抗癌和抗HIV治疗方面的研究工作。
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