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[应用颊黏膜一期矫正阴囊型和会阴型尿道下裂]

[One-stage correction of scrotal and perineal hypospadias with buccal mucosa].

作者信息

Westenfelder M, Möhring C

机构信息

Klinik für Urologie und Kinderurologie, Krankenhaus Maria-Hilf Krefeld, Oberdiessemer Strasse 94, Krefeld, Germany.

出版信息

Urologe A. 2007 Dec;46(12):1647-56. doi: 10.1007/s00120-007-1574-4.

Abstract

Delayed correction of genital malformations can have a negative influence on the emotional, psychosocial and cognitive development. Early one-stage-correction to give as near-normal an appearance and function as possible is therefore desirable. This can now be realized in most forms of hypospadias. However, in the rare and most severe forms (5-6%; scrotal and perineal forms) this is technically very demanding. It is extremely difficult for a surgeon to accumulate enough relevant experience, so that one-stage correction is performed only by very few. To investigate results with one-step correction, 100 of 163 cases treated up to 2006 were analyzed. Analysis of the first group of 50 consecutive cases operated on between 1996 and 2001 showed a complication/reoperation rate of 22% (11 cases). The 11 children required a total of 18 (36%) corrective surgical interventions. In 42 cases buccal mucosa was used as a tube onlay. In this group one- stage correction was successful in 39 (78%); 4 patients required two operations and 7 three. Children in group II were consecutive patients operated on between 2003 and 2006. In this group there was a reoperation rate of 12% (6 cases, in 1 of which severe lack of skin made one-stage correction technically impossible). In 45 cases buccal mucosa was used for a tube-onlay. Thus, in group II 44 patients (88%) underwent successful one-stage correction and 6 had two operations; none had three. The significantly lower complication rate in group II is presumably due to greater experience of the surgeons. All strictures observed developed at the level of the glans. In no case was buccal mucosa rejected; nor did any strictures develop between urethra and neo-urethra, being reliably prevented by the connection, with an onlay, to the recessed urethral plate. None of the 100 children became a 'hypospadias cripple'; in all cases satisfactory correction was ultimately achieved. This means that with growing experience one-stage correction can be increasingly reliably achieved. This is not a general call for one-stage correction, but an appeal for patients with these most severe forms of hypospadias to be treated only in specialized centers with the aim of allowing experience to accumulate there so that the results become more reliable.

摘要

生殖器畸形的延迟矫正会对情感、心理社会和认知发展产生负面影响。因此,早期进行一期矫正以尽可能恢复接近正常的外观和功能是很有必要的。现在,大多数类型的尿道下裂都可以实现这一点。然而,对于罕见且最严重的类型(5 - 6%;阴囊型和会阴型),这在技术上要求非常高。外科医生极难积累足够的相关经验,所以只有极少数人能进行一期矫正。为了研究一期矫正的效果,对截至2006年治疗的163例病例中的100例进行了分析。对1996年至2001年连续手术的第一组50例病例的分析显示,并发症/再次手术率为22%(11例)。这11名儿童总共需要18次(36%)矫正手术干预。在42例中使用颊黏膜作为管状覆盖物。在这组中,一期矫正成功的有39例(78%);4例患者需要进行两次手术,7例需要三次。第二组儿童是2003年至2006年连续手术的患者。在这组中,再次手术率为12%(6例,其中1例因严重皮肤缺损导致一期矫正在技术上无法进行)。在45例中使用颊黏膜进行管状覆盖。因此,在第二组中,44例患者(88%)一期矫正成功,6例进行了两次手术;无人进行三次手术。第二组并发症发生率显著较低可能是由于外科医生经验更丰富。观察到的所有狭窄均发生在龟头水平。在任何情况下,颊黏膜均未被排斥;尿道与新尿道之间也未出现狭窄,通过与凹陷的尿道板进行覆盖连接可靠地预防了狭窄。100名儿童中没有一人成为“尿道下裂残废”;所有病例最终都实现了满意的矫正。这意味着随着经验的增加,一期矫正可以越来越可靠地实现。这并不是普遍呼吁进行一期矫正,而是呼吁只有在专门的中心对这些最严重类型的尿道下裂患者进行治疗,以便在那里积累经验,使结果变得更可靠。

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