Dhir Aruna Alahari, Sawant Sheela, Dikshit Rajesh P, Parikh Purvish, Srivastava Shyam, Badwe Rajan, Rajadhyaksha Sunil, Dinshaw K A
Department of General Medicine, Tata Memorial Hospital, Parel, Mumbai, Maharashtra, India.
Cancer Causes Control. 2008 Mar;19(2):147-53. doi: 10.1007/s10552-007-9080-y. Epub 2007 Nov 9.
To study the cancer pattern among HIV positive cancer cases.
The study group included patients registered in the HIV Cancer clinic at the Tata Memorial Hospital (TMH), Mumbai, which is the largest tertiary referral cancer center in India. We used the gender and age-specific proportions of each cancer site of the year 2002 that was recorded in the Hospital Cancer Registry to estimate an expected number of various cancer sites among HIV positive cancer patients during the period 2001-2005. The observed number of site-specific cancer cases was divided by the expected number to obtain proportional incidence ratio (PIR).
No case of Kaposi's sarcoma was observed. Increased proportion of non-Hodgkin's lymphoma (NHL) was observed (PIR in males = 17.1, 95%CI 13.33-21.84, females = 10.3, 95%CI 6.10-17.41). In males, PIR was increased for anal cancer (PIR = 10.3, 95%CI 4.30-24.83), Hodgkin's disease, testicular cancer, colon cancer, and few head and neck cancer sites. Among females, the PIRs for cervical cancer (PIR = 4.1, 95%CI 2.90-5.75), vaginal cancer (PIR = 7.7, 95%CI 2.48-23.85), and anal cancer (PIR = 6.5, 95%CI 0.91-45.88) were increased.
The absence of Kaposi's sarcoma and increased PIRs for certain non-AIDS defining cancers among HIV infected cancer cases indicates a different spectrum of HIV associated malignancies in this region. The raised PIR for cervical cancer emphasizes the urgent need for screening programs for cervical cancer among HIV infected individuals in India.
研究HIV阳性癌症病例中的癌症模式。
研究组包括在印度最大的三级转诊癌症中心孟买塔塔纪念医院（TMH）的HIV癌症诊所登记的患者。我们使用医院癌症登记处记录的2002年各癌症部位的性别和年龄特异性比例，来估计2001 - 2005年期间HIV阳性癌症患者中各种癌症部位的预期数量。将特定部位癌症病例的观察数量除以预期数量，以获得比例发病率（PIR）。
未观察到卡波西肉瘤病例。观察到非霍奇金淋巴瘤（NHL）的比例增加（男性PIR = 17.1，95%CI 13.33 - 21.84；女性PIR = 10.3，95%CI 6.10 - 17.41）。在男性中，肛门癌（PIR = 10.3，95%CI 4.30 - 24.83）、霍奇金病、睾丸癌、结肠癌以及少数头颈癌部位的PIR增加。在女性中，宫颈癌（PIR = 4.1，95%CI 2.90 - 5.75）、阴道癌（PIR = 7.7，95%CI 2.48 - 23.85）和肛门癌（PIR = 6.5，95%CI 0.91 - 45.88）的PIR增加。
HIV感染癌症病例中未出现卡波西肉瘤，且某些非艾滋病定义癌症的PIR增加，表明该地区HIV相关恶性肿瘤谱有所不同。宫颈癌升高的PIR强调了印度迫切需要为HIV感染者开展宫颈癌筛查项目。
