Luyckx A S, Lefebvre P J
Horm Metab Res. 1976;Suppl 6:26-33.
The transplantable islet-cell tumor of the golden hamster has already been shown to produce hypoglycemia and hyperinsulinemia in the receptor animal. The present study demonstrates that the plasma pancreatic glucagon concentrations are significantly increased in the tumor-bearing animals but that this hyperglucagonemia is not abolished by administration of glucose or of diazoxide. It is also unresponsive to arginine administrations. In these animals, increased peripheral glucagon plasma concentrations are observed along with a reduced porto-aortic glucagon gradient. Moreover, plasma glucagon in the vena cava is usually higher than that in the aorta and a significant quantity of glucagon is found in the tumor. We conclude that glucagon release from the tumor is in fact responsible for the observed hyperglucagonemia.
金黄仓鼠的可移植胰岛细胞瘤已被证明能在受体动物中引起低血糖和高胰岛素血症。本研究表明，荷瘤动物的血浆胰高血糖素浓度显著升高，但给予葡萄糖或二氮嗪并不能消除这种高胰高血糖素血症。它对给予精氨酸也无反应。在这些动物中，外周血浆胰高血糖素浓度升高，同时门静脉-主动脉胰高血糖素梯度降低。此外，腔静脉中的血浆胰高血糖素通常高于主动脉中的，并且在肿瘤中发现了大量胰高血糖素。我们得出结论，肿瘤释放的胰高血糖素实际上是导致观察到的高胰高血糖素血症的原因。
