Dunbar J C, Walsh M F, Foa P P
Diabete Metab. 1976 Dec;2(4):165-9.
Glucose, insulin (IRI), pancreatic (IRG) and total (GLI) immunoreactive glucagon were measured in the serum of normal hamsters and of hamsters with an insulin- and glucagon-secreting, transplantable insuloma. The tumor-bearing animals were hypoglycemic, hyperinsulinemic and hyperglucagonemic. The pancreatic islets of tumor-bearing animals secreted less glucagon and insulin in response to arginine or to changes in the glucose concentration of the medium, than did the islets of control hamsters. In addition, the introduction of glucose into the gastro-intestinal tract, which caused a significant rise in the serum GLI concentration of normal hamsters, failed to do so in the tumor-bearing animals. The results suggest that the high levels of serum glucagon and insulin induced by the tumor, suppressed IRI, IRG and GLI secretion in these animals.
在正常仓鼠以及患有可移植性胰岛素瘤（能分泌胰岛素和胰高血糖素）的仓鼠血清中，检测了葡萄糖、胰岛素（IRI）、胰腺（IRG）和总（GLI）免疫反应性胰高血糖素。患瘤动物出现低血糖、高胰岛素血症和高胰高血糖素血症。与对照仓鼠的胰岛相比，患瘤动物的胰岛对精氨酸或培养基中葡萄糖浓度变化的反应分泌的胰高血糖素和胰岛素更少。此外，将葡萄糖引入胃肠道会使正常仓鼠的血清GLI浓度显著升高，但在患瘤动物中却未能如此。结果表明，肿瘤诱导的血清高胰高血糖素和胰岛素水平抑制了这些动物的IRI、IRG和GLI分泌。
