Liu Lei, Chen Yu-ping, Wan Zhe, Li An-liang, Li Ruo-yu, Tu Peng-fei
School of Pharmaceutical Sciences, Peking University, Beijing 100083, China.
Zhongguo Zhong Yao Za Zhi. 2007 Sep;32(17):1762-5.
To investigate the chemical constituents of Pyrola calliatha.
The chemical constituents were isolated by various column chromatographic methods. The structures were identified by spectral data.
Ten compounds were isolated and identified as chimaphilin (1), uvaol(2), ursolic acid (3), 2beta,3beta,23-trihydroxy-12-ene-28-ursolic acid (4), daucosterol (5), 2alpha,3beta,23,24-tetrahydroxy-12-ene-28-ursolic acid (6), emodin (7), gallic acid (8), monotropein (9), adenosine (10).
Compounds 2,4,6,7,10 were obtained from this genus for the first time, compounds 5, 9 were obtained from this species for the first time. Antifungal activity of compounds 1-4, 6-9 were evaluated. Compound 1 showed the strong activity.
研究鹿蹄草的化学成分。
采用多种柱色谱方法分离化学成分，通过光谱数据鉴定结构。
分离鉴定出10个化合物，分别为喜冬草素（1）、羽扇豆醇（2）、熊果酸（3）、2β,3β,23-三羟基-12-烯-28-乌苏酸（4）、胡萝卜苷（5）、2α,3β,23,24-四羟基-12-烯-28-乌苏酸（6）、大黄素（7）、没食子酸（8）、水晶兰苷（9）、腺苷（10）。
化合物2、4、6、7、10为首次从该属植物中分得，化合物5、9为首次从该种植物中分得。对化合物1 - 4、6 - 9进行了抗真菌活性评价，化合物1表现出较强活性。
