栀子苷的植物化学、药理学、药代动力学和毒理学研究进展：一种天然产物。
A Review on the Phytochemistry, Pharmacology, Pharmacokinetics and Toxicology of Geniposide, a Natural Product.
机构信息
Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China.
National Key Laboratory of Pharmaceutical New Technology for Chinese Medicine, Jiangsu Kanion Pharmaceutical Co. Ltd., Lianyungang 222001, China.
出版信息
Molecules. 2017 Oct 10;22(10):1689. doi: 10.3390/molecules22101689.
Iridoid glycosides are natural products occurring widely in many herbal plants. Geniposide (CHO) is a well-known one, present in nearly 40 species belonging to various families, especially the Rubiaceae. Along with this herbal component, dozens of its natural derivatives have also been isolated and characterized by researchers. Furthermore, a large body of pharmacological evidence has proved the various biological activities of geniposide, such as anti-inflammatory, anti-oxidative, anti-diabetic, neuroprotective, hepatoprotective, cholagogic effects and so on. However, there have been some research articles on its toxicity in recent years. Therefore, this review paper aims to provide the researchers with a comprehensive profile of geniposide on its phytochemistry, pharmacology, pharmacokinetics and toxicology in order to highlight some present issues and future perspectives as well as to help us develop and utilize this iridoid glycoside more efficiently and safely.
环烯醚萜苷类是广泛存在于多种药用植物中的天然产物。京尼平苷（CHO）是一种众所周知的环烯醚萜苷，存在于近 40 种属于不同科的植物中，尤其是茜草科。除了这种草药成分外，研究人员还分离和鉴定了其数十种天然衍生物。此外，大量的药理学证据证明了京尼平苷具有多种生物学活性，如抗炎、抗氧化、抗糖尿病、神经保护、保肝、利胆等作用。然而，近年来关于其毒性的研究文章也有一些。因此，本综述旨在为研究人员提供京尼平苷在植物化学、药理学、药代动力学和毒理学方面的综合概况，以突出一些当前的问题和未来的展望，并帮助我们更有效地、更安全地开发和利用这种环烯醚萜苷。
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