[Hypnotic effect of Chinese materia medica Cynanchum chinese in mice].

OBJECTIVE

To study the central pharmacological effect of the water and chloroform-extract compounds from C. chinese in mice.

METHOD

The independent activity test and the hypnotic synergism test by sub-threshold hypnotic dosage of pentobarbital were employed to evaluate the central pharmacological effect of the extract-compounds, and the minimal neurotoxicity was evaluated by the rotorod test.

RESULT

the extract-compounds exhibited significant dose-related inhibition effect of the spontaneous motor activity in mice after intraperitoneal administration. And the two extract-compounds promoted the hypnotic effect by sub-threshold hypnotic dosage administration of pentobarbital, and produced ED50 value of 2.36 g kg (-1) and 0.75 g kg(-1), respectively. Also, both extract-compounds showed no neurotoxicity in the experiment.

CONCLUSION

The extract compounds from C. chinese showed inhibitional effect on CNS.