Sinha Saurabh
Department of Computer Science, University of Illinois, USA.
Methods Mol Biol. 2007;395:309-18.
Discovery of transcription factor binding sites is a crucial and challenging problem in bioinformatics. Several computational tools have been developed for this problem, popularly known as the motif-finding problem. PhyME is an ab initio motif-finding algorithm, which finds overrepresented motifs in input sequences while accounting for their evolutionary conservation in orthologs of those sequences. Here, we describe the usage of this algorithm, publicly available as a Linux-based implementation.
转录因子结合位点的发现是生物信息学中一个关键且具有挑战性的问题。针对这个问题已经开发了几种计算工具，通常被称为基序查找问题。PhyME是一种从头基序查找算法，它在输入序列中查找过度表达的基序，同时考虑这些序列直系同源物中的进化保守性。在这里，我们描述这种算法的用法，它作为基于Linux的实现可公开获取。
