神经调节蛋白-1：围产期脑白质损伤的潜在内源性保护因子。
Neuregulin-1: a potential endogenous protector in perinatal brain white matter damage.
作者信息
Dammann Olaf, Bueter Wolfgang, Leviton Alan, Gressens Pierre, Dammann Christiane E L
机构信息
Division of Newborn Medicine, Department of Pediatrics, Tufts-New England Medical Center, Boston, Mass., USA.
出版信息
Neonatology. 2008;93(3):182-7. doi: 10.1159/000111119. Epub 2007 Nov 9.
Abstract
Brain white matter damage, an important antecedent of long-term disabilities among preterm infants, has both endogenous and exogenous components. One of the endogenous components is the paucity of developmentally regulated protectors. Here we expand on this component, discussing the potential roles of one putative protector, neuregulin (NRG)-1, in brain development and damage. We outline how NRG-1 might be involved in perinatal brain damage pathomechanisms and suggest that NRG-1 might be one target for intervention.
摘要
脑白质损伤是早产儿长期残疾的一个重要先兆，它具有内源性和外源性因素。内源性因素之一是发育调控保护因子的缺乏。在此，我们详细阐述这一因素，探讨一种假定的保护因子——神经调节蛋白（NRG）-1在脑发育和损伤中的潜在作用。我们概述了NRG-1可能如何参与围产期脑损伤的发病机制，并提出NRG-1可能是一个干预靶点。
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