从小鼠腹腔细胞中释放出两种不同的淋巴细胞刺激可溶性因子（LAF）。I. 细胞来源及环磷酸鸟苷对其释放的影响。
Two distinct lumphocyte-stimulating soluble factors (LAF) released from murine peritoneal cells. I. The cellular source and the effect of cGMP on their release.
作者信息
Diamantstein T, Ulmer A
出版信息
Immunology. 1976 May;30(5):741-7.
Culture fluids of murine peritoneal cells contain two distinct, non-dialysable priniciples (LAF) with thymocyte proliferation-stimulating properties. One of them is elaborated from phagocytic cells (presumably macrophages), the other is released by non-phagocytic cells (lymphocytes). cGMP added exogenously stimulates the production and/or release of LAF from phagocytic cells, but not from non-phagocytic cells. The phagocytic cells (but not the lymphocytes) require intact RNA and protein synthesis for LAF release. The action of LAF differs from those of cGMP itself by being non-dialysable, and unable to prevent the inhibitory action of cAMP on mitogen-stimulated lymphocyte proliferation.
小鼠腹膜细胞的培养液含有两种不同的、不可透析的具有刺激胸腺细胞增殖特性的物质（淋巴细胞激活因子）。其中一种由吞噬细胞（可能是巨噬细胞）产生，另一种由非吞噬细胞（淋巴细胞）释放。外源性添加的环鸟苷酸刺激吞噬细胞产生和/或释放淋巴细胞激活因子，但不刺激非吞噬细胞。吞噬细胞（而非淋巴细胞）释放淋巴细胞激活因子需要完整的RNA和蛋白质合成。淋巴细胞激活因子的作用不同于环鸟苷酸本身，它不可透析，且不能阻止环磷酸腺苷对有丝分裂原刺激的淋巴细胞增殖的抑制作用。
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