脊髓灰质炎病毒诱导的淋巴细胞刺激抑制：一种巨噬细胞介导的效应。
Poliovirus-induced suppression of lymphocyte stimulation: a macrophage-mediated effect.
作者信息
van Loon A M, van der Logt J T, van der Veen J
出版信息
Immunology. 1979 May;37(1):135-43.
Poliovirus was shown to suppress the in vitro response of human mononuclear blood cells stimulated with phytohaemagglutinin (PHA), pokeweed mitogen (PWM), tuberculin purified protein derivative (PPD) or allogeneic cells. The suppression required infectious virus and the presence of macrophages. Experiments with combined cultures of human lymphocytes stimulated with PHA, PWM, PPD or allogeneic cells, and different numbers of autologous macrophages indicated that both lymphocyte stimulation and the inhibitory effect of poliovirus increased with increasing ratio of macrophages to lymphocytes. The response of human lymphocytes to PHA also was enhanced when autologous macrophages were replaced with murine macrophages. Mouse hepatitis virus inhibited this enhancing effect whereas poliovirus failed to do so. The findings confirm our previous suggestion that poliovirus inhibits stimulation of lymphocytes by suppressing the enhancing effect of macrophages.
已证明脊髓灰质炎病毒可抑制经植物血凝素（PHA）、商陆有丝分裂原（PWM）、结核菌素纯蛋白衍生物（PPD）或同种异体细胞刺激的人单核血细胞的体外反应。这种抑制作用需要有感染性的病毒以及巨噬细胞的存在。用PHA、PWM、PPD或同种异体细胞刺激的人淋巴细胞与不同数量的自体巨噬细胞进行联合培养的实验表明，淋巴细胞刺激和脊髓灰质炎病毒的抑制作用均随着巨噬细胞与淋巴细胞比例的增加而增强。当用鼠巨噬细胞替代自体巨噬细胞时，人淋巴细胞对PHA的反应也会增强。小鼠肝炎病毒可抑制这种增强作用，而脊髓灰质炎病毒则不能。这些发现证实了我们之前的推测，即脊髓灰质炎病毒通过抑制巨噬细胞的增强作用来抑制淋巴细胞的刺激。
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