Stoops William W, Lile Joshua A, Lofwall Michelle R, Rush Craig R
Department of Behavioral Science, University of Kentucky Medical Center, Lexington, Kentucky 40536-0086, USA.
Am J Drug Alcohol Abuse. 2007;33(6):769-76. doi: 10.1080/00952990701651556.
Although cocaine dependence remains a significant public health concern, efforts to identify a pharmacotherapy have been unsuccessful. The purpose of this study was to assess the safety, tolerability, and subject-rated effects of intranasal cocaine during maintenance on aripiprazole, a novel antipsychotic with partial agonist activity at monoamine receptors implicated in the effects of cocaine. To this end, eight cocaine dependent subjects were maintained on 10 mg oral aripiprazole and placebo in counterbalanced order prior to assessing the physiological and subject-rated effects of intranasal cocaine (4, 20, 40, and 60 mg). Aripiprazole was generally devoid of effects, but did alter temperature-increasing and subject-rated effects of cocaine as a function of cocaine dose.
尽管可卡因成瘾仍然是一个重大的公共卫生问题，但寻找药物治疗方法的努力一直没有成功。本研究的目的是评估在维持服用阿立哌唑（一种对与可卡因作用相关的单胺受体具有部分激动剂活性的新型抗精神病药物）期间，鼻内使用可卡因的安全性、耐受性以及受试者报告的效果。为此，在评估鼻内使用可卡因（4、20、40和60毫克）的生理和受试者报告的效果之前，八名可卡因成瘾受试者以平衡顺序分别维持服用10毫克口服阿立哌唑和安慰剂。阿立哌唑通常没有效果，但确实改变了可卡因的升温作用以及受试者报告的效果，且这种改变是可卡因剂量的函数。
